PHARMACOGENOMICS MCQs

By Prof. Fazal Rehman Shamil
Last modified on September 12th, 2020

PHARMACOGENOMICS MCQs

1.  Which of the one is referred to as the three-dimensional shape of a protein?

a) secondary structure

b) primary structure

c)  tertiary structure

d)  quaternary structure

Answer - Click Here:
B

2. Which technique prompted the gene therapy?

a) DNA transform

b) germline manipulation

c) retroviral gene therapy

d) electroporation

Answer - Click Here:
A

3. Which of the following are examples of genetic polymorphisms?

a) Glutathione S-transferase

b) Dihydropyrimidine dehydrogenase

c) UDP-glucuronosyl transferase

d) all of these

Answer - Click Here:
D

4. Successful gene therapy face which of the following obstacle?

a) lack of research effort

b) inefficient  gene delivery

c) inability to identify genetic defects

d) none of these

Answer - Click Here:
B

5. Which of the following is most commonly occurring variant in human genome?

a) defective gene splicing

b) premature stop codon.

c) nucleotide base insertion.

d) single-nucleotide polymorphism

Answer - Click Here:
D

6. Among all of these which of the following gene increases the risk of thronbosis?

a) tamothrombin

b) mecathrombin

c) prothrombin

c) vorithrombin

Answer - Click Here:
C

7. CYP2D6 polymorphism can affect

a) drug delivery

b) toxicity

c) drug interaction  potential

d) all of these

Answer - Click Here:
B

8. Which gene predict the muscle toxicity?

a) SLCO1B1

b) ABAB2

c) LDLR

d) none of these

Answer - Click Here:
A

9. Which of the following are the sites for gene variations?

a) drug target protein

b) drug transport protein

c) drug metabolize enzyme

d) all of these

Answer - Click Here:
A

10. In which of the following mutation homologous repeat involve?

a) Large deletions

b) Nonsense mutations

c) Splicing mutations

d) Missense mutations

Answer - Click Here:
A

11. Which mutation occurs due to uv exposure?

a) chromosome breakage

b) chromosome inversion

c) thymidine dimer

d) none of these

Answer - Click Here:
C

12. Which RNA is included in splicosome?

a) rRNA

b) mRNA

c) siRNA

d) snRNA

Answer - Click Here:
D

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