1. Which of the one is referred to as the three-dimensional shape of a protein?
(A) secondary structure
(B) primary structure
(C) tertiary structure
(D) quaternary structure

2. Which technique prompted the gene therapy?
(A) DNA transform
(B) germline manipulation
(C) retroviral gene therapy
(D) electroporation

3. Which of the following are examples of genetic polymorphisms?
(A) Glutathione S-transferase
(B) Dihydropyrimidine dehydrogenase
(C) UDP-glucuronosyl transferase
(D) all of these

4. Successful gene therapy face which of the following obstacle?
(A) lack of research effort
(B) inefficient gene delivery
(C) inability to identify genetic defects
(D) none of these

5. Which of the following is most commonly occurring variant in human genome?
(A) defective gene splicing
(B) premature stop codon
(C) nucleotide base insertion
(D) single-nucleotide polymorphism

6. Among all of these which of the following gene increases the risk of thrombosis?
(A) tamothrombin
(B) mecathrombin
(C) prothrombin
(D) vorithrombin

7. CYP2D6 polymorphism can affect
(A) drug delivery
(B) toxicity
(C) drug interaction potential
(D) all of these

8. Which gene predict the muscle toxicity?
(A) SLCO1B1
(B) ABAB2
(C) LDLR
(D) none of these

9. Which of the following are the sites for gene variations?
(A) drug target protein
(B) drug transport protein
(C) drug metabolize enzyme
(D) all of these

10. In which of the following mutation homologous repeat involve?
(A) Large deletions
(B) Nonsense mutations
(C) Splicing mutations
(D) Missense mutations

11. Which mutation occurs due to UV exposure?
(A) chromosome breakage
(B) chromosome inversion
(C) thymidine dimer
(D) none of these

12. Which RNA is included in splicosome?
(A) rRNA
(B) mRNA
(C) siRNA
(D) snRNA