Question: Which enzyme converts fibrinogen to fibrin?
Answer:
- Thrombin is an enzyme that converts fibrinogen to fibrin.
- It is a serine protease that plays a crucial role in the blood clotting process.
- It converts soluble fibrinogen into insoluble fibrin strands, forming a fibrin clot.
- Thrombin is produced as an inactive form called prothrombin, which is converted into active form, through a cascade of enzymatic reactions caused by injury.
| Enzyme |
Thrombin |
| Location |
Blood plasma |
| Function |
Converts fibrinogen to fibrin during blood clot formation |
| Class |
Serine protease |
| Substrate |
Fibrinogen |
| Products |
Fibrin |
| Activation |
Prothrombin (inactive) is converted to thrombin (active) |
| Regulation |
Regulated by the coagulation cascade and various factors |
| Other Names |
Factor IIa, Blood-coagulation factor IIa |
| Optimal pH |
Around pH 7.4 |
| Optimal Temperature |
Around 37°C (body temperature) |
| Significance |
Essential for blood clot formation and hemostasis |
| Associated Organs |
Blood plasma, involved in the coagulation process |
| Other Actions |
Activates other clotting factors, amplifies the coagulation cascade |
| Inhibitors |
Antithrombin, Protein C, Protein S, tissue factor pathway inhibitor |
| Deficiency |
Thrombin deficiency is rare but can lead to bleeding disorders |
Important Questions about Enzymes
- Enzymes MCQs
- Inhibition in enzymes
- Which enzyme digests starch?
- Which enzyme digests protein?
- which enzyme is present in saliva?
- Which enzyme is not present in succus entericus?
- Which enzyme breaks down protein in the stomach?
- Which enzyme converts fibrinogen to fibrin?
- Which enzyme converts glucose into alcohol?
- Which enzyme digests fat?
- Which enzyme digests milk protein?
- Which enzyme is used in PCR?
- Which enzyme unzips the DNA double helix?
- Which liver enzyme increases with alcohol?
- Which enzyme cuts DNA?
- Which enzyme catalyzes the first step of glycolysis?
- Which enzyme binds DNA fragments together?
- Which enzyme transcribes DNA into RNA?
- which enzyme adds new nucleotides?
- Which enzyme digests cellulose?
- Which enzyme separates the two strands of DNA?
- Which enzyme converts carbohydrates into glucose?
- Which enzyme removes RNA primer?
- Which enzymes help in digestion?
- Which enzyme works best in acidic conditions?
- Which enzyme synthesizes tRNA?
- Which enzyme secreted by pancreas?
- Which enzyme converts maltose into glucose?
- Which vitamins work as coenzyme?
