Let me share with you a difference between fibrin and fibrinogen.
| Aspect | Fibrin | Fibrinogen |
| Introduction | Fibrin is an insoluble protein formed by the polymerization of fibrinogen | Fibrinogen is a soluble plasma protein and the precursor of fibrin |
| Function | Forms a mesh-like structure, providing the framework for blood clots | Acts as a precursor form of fibrin and is involved in blood clotting |
| Solubility in blood plasma | Insoluble | Soluble |
| Activation | Formed through the enzymatic cleavage of fibrinogen by thrombin during blood clotting | Activated by thrombin, which cleaves fibrinopeptides to expose binding sites for polymerization |
| Structure | Fibrin strands form a meshwork that traps blood cells to create a stable clot | Fibrinogen has three polypeptide chains: alpha, beta, and gamma, and has a rod-like structure |
| Stability | More stable | Less stable |
| Measurement in blood tests | Fibrin degradation products (FDPs) are measured to assess fibrinolysis | Fibrinogen levels are measured as a marker of blood clotting ability |