Osteosarcoma, Ewingโ€™s sarcoma MCQs

By: Prof. Dr. Fazal Rehman | Last updated: September 28, 2024

What is the most common primary malignant bone tumor in children and adolescents?
Osteosarcoma
Ewingโ€™s sarcoma
Chondrosarcoma
Giant cell tumor
Answer: Osteosarcoma

Which part of the bone is most commonly affected by osteosarcoma?
Diaphysis
Epiphysis
Metaphysis
Cortical bone
Answer: Metaphysis

What is the typical age group for Ewing’s sarcoma?
0-5 years
5-10 years
10-20 years
20-30 years
Answer: 10-20 years

What is the hallmark histological feature of Ewing’s sarcoma?
Osteoid production
Small, round, blue cells
Giant multinucleated cells
Spindle-shaped cells
Answer: Small, round, blue cells

Which bone tumor is associated with a “sunburst” appearance on radiographs?
Osteosarcoma
Ewingโ€™s sarcoma
Chondrosarcoma
Fibrous dysplasia
Answer: Osteosarcoma

What is the most common site of metastasis for osteosarcoma?
Brain
Liver
Lungs
Kidneys
Answer: Lungs

Which of the following is a common location for Ewingโ€™s sarcoma?
Distal femur
Pelvis
Humerus
Skull
Answer: Pelvis

What is the typical radiographic appearance of Ewingโ€™s sarcoma?
Ground glass appearance
Sunburst pattern
Onion skin periosteal reaction
Lytic lesions with sclerotic margins
Answer: Onion skin periosteal reaction

Which genetic translocation is commonly associated with Ewingโ€™s sarcoma?
t(9;22)
t(11;22)
t(8;14)
t(15;17)
Answer: t(11;22)

Which type of bone is most often affected by osteosarcoma?
Flat bones
Irregular bones
Long bones
Short bones
Answer: Long bones

What is the first-line treatment for osteosarcoma?
Radiation therapy
Chemotherapy
Surgical resection
Immunotherapy
Answer: Surgical resection

Which chemotherapy agent is commonly used in the treatment of osteosarcoma?
Methotrexate
Cyclophosphamide
Vincristine
Doxorubicin
Answer: Doxorubicin

Ewingโ€™s sarcoma is most commonly found in which of the following populations?
African-American
Caucasian
Asian
Native American
Answer: Caucasian

Which bone tumor is more sensitive to radiation therapy?
Osteosarcoma
Ewingโ€™s sarcoma
Chondrosarcoma
Giant cell tumor
Answer: Ewingโ€™s sarcoma

What is the 5-year survival rate for localized osteosarcoma with treatment?
Less than 10%
20-30%
50-70%
Greater than 80%
Answer: 50-70%

Which of the following bone tumors is most likely to occur in the diaphysis of long bones?
Osteosarcoma
Ewingโ€™s sarcoma
Giant cell tumor
Chondrosarcoma
Answer: Ewingโ€™s sarcoma

Which tumor is associated with pain that worsens at night and is unrelieved by rest?
Ewingโ€™s sarcoma
Chondrosarcoma
Osteosarcoma
Osteochondroma
Answer: Osteosarcoma

What is the primary mode of metastasis for Ewingโ€™s sarcoma?
Lymphatic system
Hematogenous spread
Direct invasion
Seeding along surgical tracts
Answer: Hematogenous spread

Which of the following is a risk factor for the development of osteosarcoma?
Pagetโ€™s disease
Diabetes mellitus
Ankylosing spondylitis
Rheumatoid arthritis
Answer: Pagetโ€™s disease

Which imaging modality is most commonly used to evaluate bone tumors?
X-ray
CT scan
MRI
Ultrasound
Answer: MRI

What is the typical treatment protocol for Ewingโ€™s sarcoma?
Surgery only
Chemotherapy and radiation
Radiation only
Immunotherapy
Answer: Chemotherapy and radiation

Which of the following is a characteristic of high-grade osteosarcoma?
Slow-growing
Well-circumscribed borders
Aggressive with a high metastatic potential
Involvement limited to the bone cortex
Answer: Aggressive with a high metastatic potential

Which of the following is a common presenting symptom of Ewingโ€™s sarcoma?
Night sweats
Localized pain and swelling
Jaundice
Vision changes
Answer: Localized pain and swelling

Osteosarcoma primarily arises from which type of bone tissue?
Cartilage
Fibrous tissue
Osteoid
Muscle
Answer: Osteoid

What is a poor prognostic factor in osteosarcoma?
Involvement of the distal femur
Tumor size less than 8 cm
Lung metastasis at presentation
Response to chemotherapy
Answer: Lung metastasis at presentation

Which bone tumor typically presents with systemic symptoms like fever and weight loss?
Osteosarcoma
Chondrosarcoma
Ewingโ€™s sarcoma
Osteoid osteoma
Answer: Ewingโ€™s sarcoma

Which of the following is a known complication of osteosarcoma?
Spontaneous fracture
Pulmonary embolism
Pathologic fracture
Bone infarction
Answer: Pathologic fracture

What is the most common location for osteosarcoma in the long bones?
Diaphysis
Metaphysis
Epiphysis
Cortical bone
Answer: Metaphysis

Which genetic mutation is most often associated with osteosarcoma?
TP53
BRCA1
APC
RB1
Answer: RB1

Which clinical feature distinguishes Ewingโ€™s sarcoma from osteosarcoma?
Occurrence in the diaphysis
Production of osteoid
Onion-skinning on X-ray
Metaphyseal location
Answer: Onion-skinning on X-ray

Which imaging modality is essential for staging osteosarcoma?
Bone scan
MRI
PET scan
CT of the chest
Answer: CT of the chest

Which bone tumor is more likely to occur after radiation exposure?
Osteosarcoma
Ewingโ€™s sarcoma
Chondrosarcoma
Osteoid osteoma
Answer: Osteosarcoma

What is a common feature of both osteosarcoma and Ewingโ€™s sarcoma?
Occurrence in elderly individuals
Highly metastatic potential
Poor response to chemotherapy
Arises from bone marrow cells
Answer: Highly metastatic potential

Which of the following is a less common site for metastasis in Ewingโ€™s sarcoma?
Lungs
Liver
Bone
Lymph nodes
Answer: Lymph nodes

What is the typical treatment for localized Ewingโ€™s sarcoma?
Surgical resection only
Chemotherapy and surgery
Radiation therapy only
Targeted therapy
Answer: Chemotherapy and surgery

Which condition is often mistaken for Ewingโ€™s sarcoma due to similar radiologic findings?
Osteomyelitis
Chondrosarcoma
Giant cell tumor
Fibrous dysplasia
Answer: Osteomyelitis

What is the most significant factor in determining the prognosis of osteosarcoma?
Tumor size
Age at diagnosis
Location of the tumor
Response to chemotherapy
Answer: Response to chemotherapy

What is a key difference in the treatment of osteosarcoma compared to Ewingโ€™s sarcoma?
Osteosarcoma is treated with radiation
Ewingโ€™s sarcoma requires surgical resection only
Ewingโ€™s sarcoma responds better to chemotherapy
Osteosarcoma requires less intensive treatment
Answer: Ewingโ€™s sarcoma responds better to chemotherapy

Which of the following is a characteristic feature of Ewingโ€™s sarcoma on histopathology?
Osteoid production
Large pleomorphic cells
Rosettes of small, round cells
Spindle-shaped cells
Answer: Rosettes of small, round cells

Which tumor marker is often elevated in osteosarcoma?
AFP
PSA
ALK
ALP
Answer: ALP

What is the 5-year survival rate for Ewingโ€™s sarcoma with localized disease?
Less than 10%
20-30%
50-70%
Greater than 80%
Answer: 50-70%

What is the role of limb-sparing surgery in osteosarcoma treatment?
To avoid amputation
To improve survival rate
To ensure complete tumor removal
To reduce the need for chemotherapy
Answer: To avoid amputation

Which of the following is considered an unfavorable site for osteosarcoma?
Proximal femur
Distal tibia
Distal femur
Proximal humerus
Answer: Proximal femur

What is a common post-treatment complication of Ewingโ€™s sarcoma?
Lung metastasis
Secondary malignancies
Osteonecrosis
Kidney failure
Answer: Secondary malignancies

 

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