1. Which of the following is a common first-line treatment for metastatic breast cancer?
a) Tamoxifen
b) Doxorubicin
c) Methotrexate
d) Rituximab
Answer: b) Doxorubicin
2. What is the primary mechanism of action of cisplatin?
a) Inhibition of microtubule polymerization
b) Interference with DNA replication
c) Formation of DNA cross-links
d) Inhibition of topoisomerase
Answer: c) Formation of DNA cross-links
3. In which type of cancer is the presence of the Philadelphia chromosome most commonly associated?
a) Chronic lymphocytic leukemia
b) Chronic myeloid leukemia
c) Acute myeloid leukemia
d) Acute lymphoblastic leukemia
Answer: b) Chronic myeloid leukemia
4. Which targeted therapy is commonly used in the treatment of HER2-positive breast cancer?
a) Imatinib
b) Trastuzumab
c) Bevacizumab
d) Erlotinib
Answer: b) Trastuzumab
5. What is the standard initial treatment for Stage I non-small cell lung cancer (NSCLC)?
a) Chemotherapy
b) Radiation therapy
c) Surgical resection
d) Immunotherapy
Answer: c) Surgical resection
6. Which of the following is a common side effect of the drug rituximab?
a) Cardiotoxicity
b) Nephrotoxicity
c) Infusion-related reactions
d) Neuropathy
Answer: c) Infusion-related reactions
7. The use of which medication is commonly associated with the prevention of tumor lysis syndrome in patients undergoing chemotherapy?
a) Allopurinol
b) Methotrexate
c) Cyclophosphamide
d) Paclitaxel
Answer: a) Allopurinol
8. Which of the following is a hallmark feature of the drug pembrolizumab?
a) Alkylating agent
b) Monoclonal antibody targeting PD-1
c) Antimetabolite
d) Taxane-based agent
Answer: b) Monoclonal antibody targeting PD-1
9. What is the primary treatment approach for advanced prostate cancer that has spread to distant sites?
a) Surgery
b) Radiation therapy
c) Hormone therapy
d) Chemotherapy
Answer: c) Hormone therapy
10. In which cancer type is the BRCA1 or BRCA2 mutation most commonly tested?
a) Ovarian cancer
b) Colorectal cancer
c) Pancreatic cancer
d) Non-small cell lung cancer
Answer: a) Ovarian cancer
