Let me share with you a Comparison between Apoptosis and Necrosis.
| Aspect | Apoptosis | Necrosis |
| Initiation of process | Typically a controlled and programmed cell death process initiated by the cell itself or external environment signals | Necrosis often occurs as a result of cell damage or injury |
| Cell Death Regulation | Highly regulated, with specific signaling pathways and checkpoints | Lacks regulation and cell death is uncontrolled |
| Cellular Changes | Cell shrinks, condenses, and forms apoptotic bodies containing cellular debris | Cell swells, ruptures and releases cellular contents into the surrounding tissue |
| Inflammation | Minimal inflammation as cell contents are contained and phagocytosed by neighboring cells | Typically triggers inflammation due to the release of cellular contents, leading to an immune response |
| Energy Requirements | Requires energy (ATP) to complete the process | Does not require energy and often depletes ATP |
| Examples | · Normal tissue development Removal of damaged or infected cells · Immune response regulation | · Trauma · Infection · Ischemia · Toxic exposure |
| Impact on Surrounding Tissue | Minimizes damage to neighboring cells and tissues | May cause damage to surrounding tissue due to inflammation and cell rupture |
| Morphological Changes | Cell membrane remains intact and DNA fragmentation occurs | Cell membrane integrity is compromised, leading to cell lysis |