Difference between monocytes and macrophages

By: Prof. Dr. Fazal Rehman Shamil | Last updated: February 3, 2024

 

 

Let me share with you a difference between monocytes and macrophages.

AspectMonocytesMacrophages
IntroductionA type of white blood cell (leukocyte)A type of immune cell derived from monocytes
ProductionProduced in the bone marrowMonocytes migrate to various tissues and differentiate into macrophages
CirculationCirculate in the bloodstream as part of white blood cellsFound in tissues, organs and lymphoid structures
Nucleus Large, kidney-shaped or oval nucleusLarge, irregular-shaped nucleus
Antigen PresentationLimited role in antigen presentationImportant in antigen presentation to activate T cells and initiate immune responses
PresencePresent in the bloodstream and can migrate into tissuesPresent in various tissues, where they perform tissue-specific functions
Maturation TimeHave a relatively short lifespan in circulation of about 1-3 daysCan have a longer lifespan, ranging from several weeks to months, depending on the tissue environment
Examples

 

·        Monocytes

 

·        Alveolar macrophages

·        Kupffer cells

·        Microglia