Comparison between Gram positive and Gram negative bacteria

Let me share with you a comparison between Gram positive and Gram negative bacteria.

Aspect Gram-Positive Bacteria Gram-Negative Bacteria
Chemical makeup of cell wall The cell wall is primarily composed of a thick layer of peptidoglycan. The cell wall contains a thin layer of peptidoglycan surrounded by an outer membrane.
Outer Membrane Absent Present
Plasma Membrane Contains a plasma membrane just beneath the cell wall Contains a plasma membrane beneath the thin peptidoglycan layer and an outer membrane
Periplasmic Space Smaller or absent periplasmic space Larger periplasmic space
Lipopolysaccharides (LPS) Absent Present in the outer membrane, including lipopolysaccharides (LPS)
Staining Reaction Retains the crystal violet stain during Gram staining, appearing purple under the microscope. Takes up the counterstain (safranin or fuchsin) during Gram staining, appearing pink under the microscope.
Teichoic Acids Present (lipoteichoic and wall teichoic acids) Absent or minimal presence
Susceptibility to Antibiotics Generally more susceptible to antibiotics Often more resistant to antibiotics
Porins Fewer porins in the cell wall Abundant porins in the outer membrane
Exotoxins and Endotoxins Often produces exotoxins May produce both exotoxins and endotoxins
Resistance to Environmental Stress Generally more resistant to environmental stress More susceptible to environmental stress
Examples ·        Staphylococcus

·        Streptococcus

·        Bacillus

·        Escherichia

·        Salmonella

·        Pseudomonas

·        Neisseria

Common Infections ·        Skin infections

·        Some gastrointestinal infections

·        Gastrointestinal infections

·        Respiratory infections

·        urinary tract infections

·        sepsis