1. The most common autoimmune disease worldwide is:
(A) Rheumatoid arthritis
(B) Systemic lupus erythematosus
(C) Sjögren’s syndrome
(D) Ankylosing spondylitis
2. Morning stiffness lasting more than 1 hour is characteristic of:
(A) Osteoarthritis
(B) Rheumatoid arthritis
(C) Gout
(D) Septic arthritis
3. The most specific antibody for rheumatoid arthritis is:
(A) ANA
(B) Anti-dsDNA
(C) Anti-CCP
(D) Rheumatoid factor
4. Swan-neck deformity is seen in:
(A) Rheumatoid arthritis
(B) Osteoarthritis
(C) Gout
(D) Scleroderma
5. The hallmark radiological finding in rheumatoid arthritis is:
(A) Osteophytes
(B) Periarticular osteopenia and erosions
(C) Bamboo spine
(D) Subchondral sclerosis
6. The most common extra-articular manifestation of rheumatoid arthritis is:
(A) Rheumatoid nodules
(B) Pleuritis
(C) Vasculitis
(D) Pericarditis
7. Which HLA type is strongly associated with ankylosing spondylitis?
(A) HLA-B27
(B) HLA-DR3
(C) HLA-DR4
(D) HLA-B8
8. Bamboo spine appearance is a feature of:
(A) Rheumatoid arthritis
(B) Ankylosing spondylitis
(C) Osteoarthritis
(D) Psoriatic arthritis
9. Schober’s test is used in the diagnosis of:
(A) Gout
(B) Ankylosing spondylitis
(C) Rheumatoid arthritis
(D) Systemic lupus erythematosus
10. Uveitis is commonly associated with:
(A) Rheumatoid arthritis
(B) Ankylosing spondylitis
(C) Osteoarthritis
(D) Scleroderma
11. The butterfly rash is seen in:
(A) Rheumatoid arthritis
(B) Systemic lupus erythematosus
(C) Dermatomyositis
(D) Psoriasis
12. The most specific antibody for systemic lupus erythematosus (SLE) is:
(A) Anti-CCP
(B) Anti-dsDNA
(C) Anti-Smith
(D) ANA
13. Libman-Sacks endocarditis is associated with:
(A) Rheumatoid arthritis
(B) SLE
(C) Gout
(D) Dermatomyositis
14. Raynaud’s phenomenon is most commonly seen in:
(A) Scleroderma
(B) Osteoarthritis
(C) Gout
(D) Septic arthritis
15. Sclerodactyly is a feature of:
(A) Rheumatoid arthritis
(B) Scleroderma
(C) Gout
(D) Psoriasis
16. CREST syndrome includes all except:
(A) Calcinosis
(B) Raynaud’s phenomenon
(C) Esophageal dysmotility
(D) Tenosynovitis
17. Which antibody is highly specific for scleroderma?
(A) Anti-Scl-70
(B) Anti-dsDNA
(C) Anti-CCP
(D) Anti-Jo-1
18. The most common cause of acute monoarthritis in adults is:
(A) Rheumatoid arthritis
(B) Gout
(C) Osteoarthritis
(D) Psoriatic arthritis
19. Podagra refers to involvement of:
(A) Knee joint
(B) Big toe (1st MTP joint)
(C) Wrist joint
(D) Ankle joint
20. Tophi are deposits of:
(A) Calcium
(B) Uric acid crystals
(C) Cholesterol
(D) Amyloid
21. Which crystals are negatively birefringent under polarized light?
(A) Calcium pyrophosphate
(B) Uric acid (monosodium urate)
(C) Cholesterol
(D) Oxalate
22. Pseudogout is caused by deposition of:
(A) Monosodium urate
(B) Calcium pyrophosphate dihydrate
(C) Calcium oxalate
(D) Hydroxyapatite
23. Chondrocalcinosis is seen in:
(A) Gout
(B) Pseudogout
(C) Osteoarthritis
(D) Ankylosing spondylitis
24. The most common joint affected in osteoarthritis is:
(A) Hip
(B) Knee
(C) Wrist
(D) Shoulder
25. Heberden’s nodes are seen in:
(A) Rheumatoid arthritis
(B) Osteoarthritis
(C) Gout
(D) Psoriatic arthritis
26. Bouchard’s nodes occur at:
(A) DIP joints
(B) PIP joints
(C) MCP joints
(D) Wrist joints
27. Pencil-in-cup deformity on X-ray is typical of:
(A) Rheumatoid arthritis
(B) Psoriatic arthritis
(C) Gout
(D) Osteoarthritis
28. Dactylitis (“sausage digit”) is seen in:
(A) Osteoarthritis
(B) Psoriatic arthritis
(C) SLE
(D) Rheumatoid arthritis
29. The most common systemic vasculitis in adults is:
(A) Takayasu arteritis
(B) Giant cell arteritis
(C) Polyarteritis nodosa
(D) Wegener’s granulomatosis
30. Polymyalgia rheumatica is strongly associated with:
(A) Scleroderma
(B) Giant cell arteritis
(C) Rheumatoid arthritis
(D) Ankylosing spondylitis
31. A patient with temporal headache, jaw claudication, and vision loss likely has:
(A) Polyarteritis nodosa
(B) Giant cell arteritis
(C) SLE
(D) Takayasu arteritis
32. Polyarteritis nodosa is associated with:
(A) Hepatitis B infection
(B) HIV
(C) Tuberculosis
(D) Malaria
33. Wegener’s granulomatosis is associated with:
(A) p-ANCA
(B) c-ANCA
(C) ANA
(D) Anti-dsDNA
34. Churg-Strauss syndrome is associated with:
(A) c-ANCA
(B) p-ANCA
(C) Anti-Smith antibody
(D) Anti-CCP
35. Polymyositis primarily affects:
(A) Joints
(B) Muscles
(C) Skin
(D) Bones
36. Heliotrope rash is seen in:
(A) Dermatomyositis
(B) Scleroderma
(C) Psoriasis
(D) Rheumatoid arthritis
37. Gottron’s papules are diagnostic of:
(A) Dermatomyositis
(B) Psoriasis
(C) SLE
(D) Gout
38. Which antibody is associated with dermatomyositis and polymyositis?
(A) Anti-Jo-1
(B) Anti-Scl-70
(C) Anti-Smith
(D) Anti-CCP
39. Sjögren’s syndrome is characterized by:
(A) Dry eyes and dry mouth
(B) Skin rash and arthritis
(C) Muscle weakness and rash
(D) Raynaud’s phenomenon and dysphagia
40. The most specific antibody for Sjögren’s syndrome is:
(A) Anti-Ro (SSA) and Anti-La (SSB)
(B) Anti-dsDNA
(C) Anti-Smith
(D) Anti-CCP
41. Felty’s syndrome is a triad of:
(A) Arthritis, anemia, hepatomegaly
(B) Arthritis, splenomegaly, neutropenia
(C) Arthritis, fever, pericarditis
(D) Arthritis, lymphadenopathy, thrombocytopenia
42. Still’s disease is a subtype of:
(A) Adult-onset rheumatoid arthritis
(B) Juvenile idiopathic arthritis
(C) SLE
(D) Vasculitis
43. The gold standard test for diagnosing gout is:
(A) Serum uric acid level
(B) Synovial fluid analysis for crystals
(C) X-ray
(D) Ultrasound
44. Allopurinol is used for:
(A) Acute gout attack
(B) Chronic uric acid control
(C) Pain relief in osteoarthritis
(D) Rheumatoid arthritis management
45. Colchicine is mainly used in:
(A) Osteoarthritis
(B) Acute gout attack
(C) Ankylosing spondylitis
(D) Scleroderma
46. Methotrexate is the first-line DMARD for:
(A) Osteoarthritis
(B) Rheumatoid arthritis
(C) Psoriasis only
(D) Gout
47. Hydroxychloroquine is especially useful in:
(A) SLE
(B) Gout
(C) Osteoarthritis
(D) Ankylosing spondylitis
48. Biologics such as infliximab act against:
(A) TNF-alpha
(B) IL-1
(C) IL-6
(D) T-cells
49. Which vasculitis affects large vessels?
(A) Takayasu arteritis
(B) Microscopic polyangiitis
(C) Henoch-Schönlein purpura
(D) Churg-Strauss syndrome
50. Takayasu arteritis is also known as:
(A) Pulseless disease
(B) Breakbone fever
(C) Blackwater fever
(D) Bamboo spine disease