Paget’s disease of bone MCQs

By: Prof. Dr. Fazal Rehman Shamil | Last updated: September 28, 2024

What is Paget’s disease of bone primarily characterized by?
a) Increased bone density
b) Disorganized bone remodeling
c) Decreased calcium absorption
d) Softening of bones
Answer: b) Disorganized bone remodeling

At what age does Paget’s disease typically present?
a) Childhood
b) Young adulthood
c) Middle age and older
d) Elderly only
Answer: c) Middle age and older

What is the most common symptom of Paget’s disease?
a) Severe headaches
b) Bone pain
c) Muscle weakness
d) Skin rashes
Answer: b) Bone pain

Which of the following is a common complication of Paget’s disease?
a) Osteoporosis
b) Osteosarcoma
c) Fractures
d) All of the above
Answer: c) Fractures

What is the main cause of Paget’s disease?
a) Genetic factors
b) Viral infections
c) Nutritional deficiencies
d) Hormonal imbalances
Answer: a) Genetic factors

Which bone is most commonly affected by Paget’s disease?
a) Femur
b) Skull
c) Spine
d) Humerus
Answer: b) Skull

What imaging modality is typically used to diagnose Paget’s disease?
a) MRI
b) CT scan
c) X-ray
d) Ultrasound
Answer: c) X-ray

What is a classic radiographic finding in Paget’s disease?
a) Osteopenia
b) Cortical thickening
c) Spinal stenosis
d) Joint effusion
Answer: b) Cortical thickening

What laboratory test is commonly elevated in patients with Paget’s disease?
a) Serum calcium
b) Serum phosphorus
c) Alkaline phosphatase
d) Vitamin D
Answer: c) Alkaline phosphatase

What is the primary treatment for Paget’s disease?
a) Surgery
b) Bisphosphonates
c) Calcium supplements
d) Pain relievers
Answer: b) Bisphosphonates

What is a potential effect of Paget’s disease on the skull?
a) Increased intracranial pressure
b) Decreased skull thickness
c) Normal skull structure
d) Enhanced cognitive function
Answer: a) Increased intracranial pressure

Which of the following is NOT a risk factor for developing Paget’s disease?
a) Family history
b) Advanced age
c) Low physical activity
d) High vitamin D intake
Answer: d) High vitamin D intake

What is the common term for the bone deformities seen in Paget’s disease?
a) Osteomalacia
b) Osteogenesis
c) Pagetic deformities
d) Osteoporosis
Answer: c) Pagetic deformities

What is the potential consequence of untreated Paget’s disease?
a) Improved bone strength
b) Development of osteosarcoma
c) Decreased risk of fractures
d) Reduced mobility
Answer: b) Development of osteosarcoma

What is the goal of treatment in Paget’s disease?
a) Cure the disease completely
b) Relieve symptoms and prevent complications
c) Increase bone density to normal levels
d) Eliminate all bone pain
Answer: b) Relieve symptoms and prevent complications

Which group of patients is most likely to be diagnosed with Paget’s disease?
a) Young athletes
b) Postmenopausal women
c) Older adults
d) Children
Answer: c) Older adults

What is the main method for monitoring Paget’s disease treatment response?
a) Bone density scans
b) Symptom resolution
c) Alkaline phosphatase levels
d) Pain scales
Answer: c) Alkaline phosphatase levels

What can be a secondary complication due to Paget’s disease in the lower limbs?
a) Varicose veins
b) Osteoarthritis
c) Gout
d) Rheumatoid arthritis
Answer: b) Osteoarthritis

How does Paget’s disease affect the long bone structure?
a) Decreases bone length
b) Causes bowing and deformity
c) Makes bones more rigid
d) Improves bone density
Answer: b) Causes bowing and deformity

What is the typical progression of Paget’s disease?
a) Rapid onset and severe symptoms
b) Gradual onset with variable symptoms
c) Sudden and severe pain
d) No progression over time
Answer: b) Gradual onset with variable symptoms

What role does genetic predisposition play in Paget’s disease?
a) It has no known role
b) It increases the likelihood of developing the disease
c) It decreases the severity of symptoms
d) It causes immediate symptoms
Answer: b) It increases the likelihood of developing the disease

Which treatment may be necessary for severe deformities due to Paget’s disease?
a) Physical therapy
b) Joint replacement surgery
c) Bisphosphonates
d) Immobilization
Answer: b) Joint replacement surgery

What is a common misconception about Paget’s disease?
a) It affects only older adults
b) It is a curable condition
c) It can lead to fractures
d) It primarily affects the skull
Answer: b) It is a curable condition

What effect does Paget’s disease have on the vascularity of bone?
a) Decreases blood flow
b) Increases vascularity
c) Causes necrosis
d) Has no effect
Answer: b) Increases vascularity

Which medication is typically avoided in patients with Paget’s disease?
a) Calcium
b) NSAIDs
c) Glucocorticoids
d) Bisphosphonates
Answer: c) Glucocorticoids

What can be a sign of advanced Paget’s disease?
a) Normal bone structure
b) Severe joint pain
c) Increased flexibility
d) Heightened immune response
Answer: b) Severe joint pain

What is the typical duration for bisphosphonate therapy in Paget’s disease?
a) A few days
b) Several weeks
c) Indefinitely
d) Until symptoms resolve
Answer: b) Several weeks

Which of the following is a preventive measure against Paget’s disease?
a) Increasing sun exposure
b) Regular exercise and maintaining healthy bones
c) Decreasing calcium intake
d) Avoiding vitamin D supplements
Answer: b) Regular exercise and maintaining healthy bones

What is the pathophysiology behind Paget’s disease?
a) Osteoclast dysfunction leading to abnormal bone resorption
b) Increased osteoblast activity only
c) Vitamin D deficiency
d) Reduced physical activity
Answer: a) Osteoclast dysfunction leading to abnormal bone resorption

What kind of pain is commonly associated with Paget’s disease?
a) Sharp, shooting pain
b) Dull, aching pain
c) No pain at all
d) Sudden, intense pain
Answer: b) Dull, aching pain

Which imaging finding indicates Paget’s disease of the pelvis?
a) Anterior pelvic tilt
b) Enlarged iliac wings
c) Symmetrical femoral neck
d) Fractures
Answer: b) Enlarged iliac wings

What dietary change can benefit patients with Paget’s disease?
a) Increasing phosphorus intake
b) Reducing vitamin D consumption
c) Ensuring adequate calcium and vitamin D
d) Avoiding protein
Answer: c) Ensuring adequate calcium and vitamin D

Which of the following symptoms should prompt an evaluation for Paget’s disease?
a) Joint stiffness
b) Unexplained bone pain
c) Muscle cramps
d) Swelling of the feet
Answer: b) Unexplained bone pain

What is the long-term outlook for patients with Paget’s disease with proper management?
a) Complete recovery
b) Progressive deterioration
c) Symptom management with a good quality of life
d) Increased risk of serious complications
Answer: c) Symptom management with a good quality of life

Which factor is NOT associated with an increased risk of Paget’s disease?
a) Age over 50
b) Family history
c) Female gender
d) Obesity
Answer: c) Female gender

What might a patient experience during the active phase of Paget’s disease?
a) Heightened energy levels
b) Increased bone pain
c) Enhanced mobility
d) Stable bone structure
Answer: b) Increased bone pain

Which professional is typically involved in managing Paget’s disease?
a) Neurologist
b) Orthopedic surgeon
c) Cardiologist
d) Dermatologist
Answer: b) Orthopedic surgeon

What is a common laboratory finding in Paget’s disease besides elevated alkaline phosphatase?
a) Elevated calcium levels
b) Decreased phosphate levels
c) Elevated serum calcium
d) Normal vitamin D levels
Answer: a) Elevated calcium levels

Which intervention can help alleviate symptoms of Paget’s disease?
a) Corticosteroid injections
b) Physical therapy
c) Increased bed rest
d) Complete immobilization
Answer: b) Physical therapy

What lifestyle change may help prevent complications of Paget’s disease?
a) Increased alcohol consumption
b) Smoking cessation
c) High-intensity weightlifting
d) Minimal sun exposure
Answer: b) Smoking cessation

What is the relationship between Paget’s disease and hearing loss?
a) No relationship
b) Hearing loss can occur due to skull involvement
c) Hearing loss is always present
d) It improves hearing
Answer: b) Hearing loss can occur due to skull involvement

What might a physical exam reveal in a patient with Paget’s disease?
a) Normal range of motion
b) Swelling over affected bones
c) Decreased blood pressure
d) Fluctuating heart rate
Answer: b) Swelling over affected bones

What is the role of osteoclasts in Paget’s disease?
a) They stimulate bone formation
b) They are responsible for abnormal bone resorption
c) They repair bone fractures
d) They maintain bone density
Answer: b) They are responsible for abnormal bone resorption

What is a major goal of pharmacotherapy in Paget’s disease?
a) Cure the disease
b) Prevent fractures and alleviate pain
c) Normalize blood calcium levels
d) Eliminate all symptoms
Answer: b) Prevent fractures and alleviate pain

Which joint is least likely to be affected by Paget’s disease?
a) Hip
b) Knee
c) Ankle
d) Elbow
Answer: d) Elbow

What type of monitoring is important in Paget’s disease treatment?
a) Routine blood pressure checks
b) Regular kidney function tests
c) Alkaline phosphatase level monitoring
d) Bone marrow biopsies
Answer: c) Alkaline phosphatase level monitoring

What can be a sign of Paget’s disease in the pelvis?
a) Widening of the pelvic inlet
b) Narrowing of the pelvic outlet
c) Normal pelvic dimensions
d) Increased bone density
Answer: a) Widening of the pelvic inlet

What is an effective pain management strategy for Paget’s disease?
a) Complete rest
b) Over-the-counter pain relievers
c) High-dose narcotics
d) Non-pharmacological therapies only
Answer: b) Over-the-counter pain relievers

What is the significance of elevated alkaline phosphatase in Paget’s disease?
a) It indicates liver dysfunction
b) It reflects increased osteoblastic activity
c) It signifies kidney impairment
d) It has no relevance
Answer: b) It reflects increased osteoblastic activity

Which skeletal location has the highest prevalence of Paget’s disease?
a) Hands
b) Feet
c) Spine
d) Pelvis
Answer: d) Pelvis

What is a less common symptom of Paget’s disease?
a) Hearing loss
b) Tooth movement
c) Skin discoloration
d) Vision changes
Answer: c) Skin discoloration

 

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