Metastatic bone disease MCQs

By: Prof. Dr. Fazal Rehman | Last updated: September 28, 2024

Which of the following is the most common source of metastatic bone disease? Lung Breast Kidney Prostate Answer: Breast Which type of cancer most frequently metastasizes to bone in males? Prostate Lung Colon Thyroid Answer: Prostate What is the most common site for bone metastasis? Skull Pelvis Vertebrae Humerus Answer: Vertebrae Which of the following is a common symptom of metastatic bone disease? Joint stiffness Fever Bone pain Skin rash Answer: Bone pain Which diagnostic tool is most sensitive for detecting bone metastases? X-ray CT scan Bone scan Ultrasound Answer: Bone scan Which type of bone lesion is commonly associated with prostate cancer metastasis? Osteolytic lesions Osteoblastic lesions Mixed lytic and blastic lesions Cystic lesions Answer: Osteoblastic lesions Breast cancer commonly produces which type of bone lesion in metastasis? Osteoblastic Osteolytic Cystic Erosive Answer: Osteolytic Which serum marker is often elevated in patients with bone metastasis? Alkaline phosphatase Prostate-specific antigen (PSA) Carcinoembryonic antigen (CEA) B-type natriuretic peptide (BNP) Answer: Alkaline phosphatase Which of the following cancers is least likely to metastasize to bone? Breast Colon Lung Kidney Answer: Colon What is the preferred treatment for pain relief in patients with bone metastases? Opioids Nonsteroidal anti-inflammatory drugs (NSAIDs) Radiation therapy Bisphosphonates Answer: Radiation therapy Which imaging modality is best for assessing the structural integrity of bones with metastases? X-ray MRI CT scan Bone scintigraphy Answer: CT scan What is the purpose of using bisphosphonates in metastatic bone disease? Pain relief Slowing bone resorption Stimulating bone growth Reducing tumor size Answer: Slowing bone resorption Which type of bone metastasis is more likely to result in fractures? Osteoblastic Osteolytic Mixed lesions Cystic lesions Answer: Osteolytic Which type of cancer is most likely to cause osteolytic bone metastasis? Breast Prostate Lung Kidney Answer: Breast What is the most common complication of bone metastases? Fractures Neurological deficits Hypercalcemia Joint contracture Answer: Fractures Which hormone therapy is commonly used for prostate cancer that has metastasized to bone? Tamoxifen Aromatase inhibitors Androgen deprivation therapy Bisphosphonates Answer: Androgen deprivation therapy Which of the following is a major risk factor for metastatic bone disease? Radiation exposure Prolonged immobility Advanced cancer stage Excessive calcium intake Answer: Advanced cancer stage What is a common clinical feature of spinal bone metastasis? Severe joint pain Radicular pain and neurological symptoms Severe muscle cramps Thinning hair Answer: Radicular pain and neurological symptoms Which cancer is most likely to produce both osteolytic and osteoblastic metastases? Prostate Lung Breast Kidney Answer: Breast What is the main goal of treatment for metastatic bone disease? Cure the cancer Relieve pain and prevent complications Increase bone density Prevent metastasis to other organs Answer: Relieve pain and prevent complications What is a common site for pathologic fractures in patients with bone metastases? Proximal femur Distal radius Skull Metatarsals Answer: Proximal femur What condition is commonly associated with osteolytic bone metastasis? Hypercalcemia Hypocalcemia Bone marrow suppression Hypertension Answer: Hypercalcemia Which radiographic feature is typical of osteolytic bone metastases? Bone sclerosis Bone thinning Moth-eaten appearance Sunburst pattern Answer: Moth-eaten appearance Which surgical treatment is most commonly used to stabilize bones affected by metastasis? External fixation Intramedullary nailing Arthroplasty Bone grafting Answer: Intramedullary nailing Which type of bone lesion is associated with kidney cancer metastasis? Osteolytic Osteoblastic Sclerotic Cystic Answer: Osteolytic Which type of imaging is preferred for detecting vertebral metastases? X-ray Bone scan CT scan MRI Answer: MRI What is the most common presentation of bone metastasis in the ribs? Swelling Localized pain Loss of range of motion Deformity Answer: Localized pain Which chemotherapy drug class is often used to treat bone metastases? Alkylating agents Taxanes Platinum compounds Anthracyclines Answer: Taxanes What is the term for a cancer that spreads to bone? Primary bone cancer Bone dysplasia Metastatic bone disease Benign bone lesion Answer: Metastatic bone disease Which of the following cancers commonly metastasizes to the pelvis? Prostate Lung Breast All of the above Answer: All of the above What is the role of radiation therapy in bone metastases? To shrink the tumor To relieve pain and prevent fractures To increase bone density To reduce blood flow to the bone Answer: To relieve pain and prevent fractures Which feature is more characteristic of bone metastasis from lung cancer? Osteoblastic lesions Osteolytic lesions Fibrotic changes Increased bone density Answer: Osteolytic lesions Which of the following is a key factor in the prognosis of bone metastasis? Tumor size Patient’s age Extent of bone involvement Type of surgery performed Answer: Extent of bone involvement Which bone is least likely to be involved in metastatic disease? Skull Pelvis Clavicle Humerus Answer: Clavicle What is the most appropriate management for a patient with metastatic spinal cord compression? Physical therapy Immediate corticosteroids and radiation Bisphosphonates Chemotherapy Answer: Immediate corticosteroids and radiation Which of the following is a characteristic of blastic bone metastases? Increased bone density Decreased calcium levels Lytic lesions Soft tissue mass formation Answer: Increased bone density Which medication class is used to prevent skeletal-related events in bone metastases? Corticosteroids Bisphosphonates NSAIDs Immunotherapy Answer: Bisphosphonates What is a key difference between bone metastasis and primary bone cancer? Bone metastasis originates from bone cells Bone metastasis is always osteoblastic Bone metastasis originates from other organs Bone metastasis is more responsive to surgery Answer: Bone metastasis originates from other organs Which symptom might indicate an impending pathologic fracture in a patient with bone metastasis? Sharp, localized pain during movement Chronic muscle cramps Intermittent numbness Fever and chills Answer: Sharp, localized pain during movement What is the term for the destruction of bone tissue caused by metastatic cancer? Bone dysplasia Pathologic fracture Osteonecrosis Osteolysis Answer: Osteolysis Which cancer is more likely to cause sclerotic bone metastasis? Prostate Lung Breast Thyroid Answer: Prostate Which of the following symptoms is most suggestive of metastatic disease to the spine? Swelling over the spine Night sweats Radicular pain and weakness Pain localized to one joint Answer: Radicular pain and weakness What is a major cause of hypercalcemia in patients with metastatic bone disease? Overproduction of bone marrow Osteoclastic bone resorption Osteoblastic bone formation Calcium absorption from diet Answer: Osteoclastic bone resorption Which treatment approach is commonly used for a solitary bone metastasis in a weight-bearing bone? Observation only Surgical stabilization and radiation Chemotherapy only Physical therapy Answer: Surgical stabilization and radiation What is the prognosis for patients with bone metastases? Excellent with treatment Poor due to widespread disease Highly variable depending on the primary cancer Curable with aggressive surgery Answer: Highly variable depending on the primary cancer Which type of bone metastasis is most likely to respond to bisphosphonates? Osteoblastic Osteolytic Mixed Cartilaginous Answer: Osteolytic Which symptom is most commonly associated with bone metastasis in the femur? Weakness Night sweats Pain with ambulation Skin discoloration Answer: Pain with ambulation  

• Bone Structure and Function MCQs
  • Anatomy of bones and joints MCQs
  • Bone remodeling and healing MCQs
  • Fracture types and classifications MCQs
• Musculoskeletal System MCQs
  • Anatomy of muscles, tendons, and ligaments MCQs
  • Joint biomechanics MCQs
• Fractures MCQs
  • Fracture management (open and closed) MCQs
  • Principles of reduction and fixation MCQs
  • Complications of fractures (e.g., nonunion, malunion, delayed healing) MCQs
  • Pathological fractures MCQs
• Orthopedic Trauma MCQs
  • Trauma assessment and classification MCQs (e.g., pelvic fractures)
  • Management of polytrauma patients MCQs
  • Open fractures and their management MCQs(Gustilo classification)
• Pediatric Orthopedics MCQs
  • Growth plate fractures MCQs
  • Developmental dysplasia of the hip (DDH) MCQs
  • Legg-Calvé-Perthes disease MCQs
  • Slipped capital femoral epiphysis (SCFE) MCQs
• Spine Disorders MCQs
  • Scoliosis and kyphosis MCQs
  • Degenerative spine conditions  MCQs (e.g., spondylolisthesis, herniated discs)
  • Spinal cord injuries MCQs
  • Management of spinal fractures MCQs
• Arthritis MCQs
  • Osteoarthritis MCQs
  • Rheumatoid arthritis MCQs
  • Juvenile idiopathic arthritis MCQs
  • Gout and other crystal arthropathies MCQs
• Bone and Joint Infections MCQs
  • Osteomyelitis MCQs
  • Septic arthritis MCQs
  • Tuberculosis of the bone (Pott’s disease) MCQs
• Bone Tumors MCQs
  • Benign vs malignant bone tumors MCQs
  • Osteosarcoma, Ewing’s sarcoma MCQs
  • Metastatic bone disease MCQs
• Soft Tissue Conditions MCQs
  • Tendon injuries MCQs(e.g., Achilles tendon rupture)
  • Ligament injuries MCQs (e.g., ACL, PCL tears)
  • Bursitis and tendinitis MCQs
• Joint Disorders MCQs
  • Shoulder impingement and rotator cuff injuries MCQs
  • Hip and knee replacements MCQs (arthroplasty)
  • Meniscal and cartilage injuries MCQs
• Sports Injuries MCQs
  • Common sports-related injuries MCQs(e.g., ACL tears, meniscus injuries)
  • Overuse injuries MCQs(e.g., stress fractures)
• Orthopedic Surgeries MCQs
  • Surgical approaches and techniques  MCQs(ORIF, external fixation, arthroscopy)
  • Complications of orthopedic surgeries MCQs
•  Bone Metabolism Disorders MCQs
  • • Osteoporosis MCQs
    • Rickets and osteomalacia MCQs
    • Paget’s disease of bone MCQs
• Prosthetics and Orthotics