Metastatic bone disease MCQs

By: Prof. Dr. Fazal Rehman Shamil | Last updated: September 28, 2024

Which of the following is the most common source of metastatic bone disease?
Lung
Breast
Kidney
Prostate
Answer: Breast

Which type of cancer most frequently metastasizes to bone in males?
Prostate
Lung
Colon
Thyroid
Answer: Prostate

What is the most common site for bone metastasis?
Skull
Pelvis
Vertebrae
Humerus
Answer: Vertebrae

Which of the following is a common symptom of metastatic bone disease?
Joint stiffness
Fever
Bone pain
Skin rash
Answer: Bone pain

Which diagnostic tool is most sensitive for detecting bone metastases?
X-ray
CT scan
Bone scan
Ultrasound
Answer: Bone scan

Which type of bone lesion is commonly associated with prostate cancer metastasis?
Osteolytic lesions
Osteoblastic lesions
Mixed lytic and blastic lesions
Cystic lesions
Answer: Osteoblastic lesions

Breast cancer commonly produces which type of bone lesion in metastasis?
Osteoblastic
Osteolytic
Cystic
Erosive
Answer: Osteolytic

Which serum marker is often elevated in patients with bone metastasis?
Alkaline phosphatase
Prostate-specific antigen (PSA)
Carcinoembryonic antigen (CEA)
B-type natriuretic peptide (BNP)
Answer: Alkaline phosphatase

Which of the following cancers is least likely to metastasize to bone?
Breast
Colon
Lung
Kidney
Answer: Colon

What is the preferred treatment for pain relief in patients with bone metastases?
Opioids
Nonsteroidal anti-inflammatory drugs (NSAIDs)
Radiation therapy
Bisphosphonates
Answer: Radiation therapy

Which imaging modality is best for assessing the structural integrity of bones with metastases?
X-ray
MRI
CT scan
Bone scintigraphy
Answer: CT scan

What is the purpose of using bisphosphonates in metastatic bone disease?
Pain relief
Slowing bone resorption
Stimulating bone growth
Reducing tumor size
Answer: Slowing bone resorption

Which type of bone metastasis is more likely to result in fractures?
Osteoblastic
Osteolytic
Mixed lesions
Cystic lesions
Answer: Osteolytic

Which type of cancer is most likely to cause osteolytic bone metastasis?
Breast
Prostate
Lung
Kidney
Answer: Breast

What is the most common complication of bone metastases?
Fractures
Neurological deficits
Hypercalcemia
Joint contracture
Answer: Fractures

Which hormone therapy is commonly used for prostate cancer that has metastasized to bone?
Tamoxifen
Aromatase inhibitors
Androgen deprivation therapy
Bisphosphonates
Answer: Androgen deprivation therapy

Which of the following is a major risk factor for metastatic bone disease?
Radiation exposure
Prolonged immobility
Advanced cancer stage
Excessive calcium intake
Answer: Advanced cancer stage

What is a common clinical feature of spinal bone metastasis?
Severe joint pain
Radicular pain and neurological symptoms
Severe muscle cramps
Thinning hair
Answer: Radicular pain and neurological symptoms

Which cancer is most likely to produce both osteolytic and osteoblastic metastases?
Prostate
Lung
Breast
Kidney
Answer: Breast

What is the main goal of treatment for metastatic bone disease?
Cure the cancer
Relieve pain and prevent complications
Increase bone density
Prevent metastasis to other organs
Answer: Relieve pain and prevent complications

What is a common site for pathologic fractures in patients with bone metastases?
Proximal femur
Distal radius
Skull
Metatarsals
Answer: Proximal femur

What condition is commonly associated with osteolytic bone metastasis?
Hypercalcemia
Hypocalcemia
Bone marrow suppression
Hypertension
Answer: Hypercalcemia

Which radiographic feature is typical of osteolytic bone metastases?
Bone sclerosis
Bone thinning
Moth-eaten appearance
Sunburst pattern
Answer: Moth-eaten appearance

Which surgical treatment is most commonly used to stabilize bones affected by metastasis?
External fixation
Intramedullary nailing
Arthroplasty
Bone grafting
Answer: Intramedullary nailing

Which type of bone lesion is associated with kidney cancer metastasis?
Osteolytic
Osteoblastic
Sclerotic
Cystic
Answer: Osteolytic

Which type of imaging is preferred for detecting vertebral metastases?
X-ray
Bone scan
CT scan
MRI
Answer: MRI

What is the most common presentation of bone metastasis in the ribs?
Swelling
Localized pain
Loss of range of motion
Deformity
Answer: Localized pain

Which chemotherapy drug class is often used to treat bone metastases?
Alkylating agents
Taxanes
Platinum compounds
Anthracyclines
Answer: Taxanes

What is the term for a cancer that spreads to bone?
Primary bone cancer
Bone dysplasia
Metastatic bone disease
Benign bone lesion
Answer: Metastatic bone disease

Which of the following cancers commonly metastasizes to the pelvis?
Prostate
Lung
Breast
All of the above
Answer: All of the above

What is the role of radiation therapy in bone metastases?
To shrink the tumor
To relieve pain and prevent fractures
To increase bone density
To reduce blood flow to the bone
Answer: To relieve pain and prevent fractures

Which feature is more characteristic of bone metastasis from lung cancer?
Osteoblastic lesions
Osteolytic lesions
Fibrotic changes
Increased bone density
Answer: Osteolytic lesions

Which of the following is a key factor in the prognosis of bone metastasis?
Tumor size
Patient’s age
Extent of bone involvement
Type of surgery performed
Answer: Extent of bone involvement

Which bone is least likely to be involved in metastatic disease?
Skull
Pelvis
Clavicle
Humerus
Answer: Clavicle

What is the most appropriate management for a patient with metastatic spinal cord compression?
Physical therapy
Immediate corticosteroids and radiation
Bisphosphonates
Chemotherapy
Answer: Immediate corticosteroids and radiation

Which of the following is a characteristic of blastic bone metastases?
Increased bone density
Decreased calcium levels
Lytic lesions
Soft tissue mass formation
Answer: Increased bone density

Which medication class is used to prevent skeletal-related events in bone metastases?
Corticosteroids
Bisphosphonates
NSAIDs
Immunotherapy
Answer: Bisphosphonates

What is a key difference between bone metastasis and primary bone cancer?
Bone metastasis originates from bone cells
Bone metastasis is always osteoblastic
Bone metastasis originates from other organs
Bone metastasis is more responsive to surgery
Answer: Bone metastasis originates from other organs

Which symptom might indicate an impending pathologic fracture in a patient with bone metastasis?
Sharp, localized pain during movement
Chronic muscle cramps
Intermittent numbness
Fever and chills
Answer: Sharp, localized pain during movement

What is the term for the destruction of bone tissue caused by metastatic cancer?
Bone dysplasia
Pathologic fracture
Osteonecrosis
Osteolysis
Answer: Osteolysis

Which cancer is more likely to cause sclerotic bone metastasis?
Prostate
Lung
Breast
Thyroid
Answer: Prostate

Which of the following symptoms is most suggestive of metastatic disease to the spine?
Swelling over the spine
Night sweats
Radicular pain and weakness
Pain localized to one joint
Answer: Radicular pain and weakness

What is a major cause of hypercalcemia in patients with metastatic bone disease?
Overproduction of bone marrow
Osteoclastic bone resorption
Osteoblastic bone formation
Calcium absorption from diet
Answer: Osteoclastic bone resorption

Which treatment approach is commonly used for a solitary bone metastasis in a weight-bearing bone?
Observation only
Surgical stabilization and radiation
Chemotherapy only
Physical therapy
Answer: Surgical stabilization and radiation

What is the prognosis for patients with bone metastases?
Excellent with treatment
Poor due to widespread disease
Highly variable depending on the primary cancer
Curable with aggressive surgery
Answer: Highly variable depending on the primary cancer

Which type of bone metastasis is most likely to respond to bisphosphonates?
Osteoblastic
Osteolytic
Mixed
Cartilaginous
Answer: Osteolytic

Which symptom is most commonly associated with bone metastasis in the femur?
Weakness
Night sweats
Pain with ambulation
Skin discoloration
Answer: Pain with ambulation