Comparison between Homozygous and Heterozygous

By: Prof. Dr. Fazal Rehman Shamil | Last updated: February 3, 2024

 

Let me share with you a comparison between Homozygous and Heterozygous.

AspectHomozygousHeterozygous
Genetic makeupTwo identical alleles for a specific gene e.g., AA or aaTwo different alleles for a specific gene e.g., Aa
DominanceBoth alleles express the same traitOne allele may be dominant, while the other may be  recessive
PhenotypeTypically expresses a specific trait related to the dominant alleleMay exhibit an intermediate trait related to both alleles
Genetic diversityLower genetic diversity in the specific geneHigher genetic diversity in the specific gene
InbreedingProne to inbreeding depression when the allele is associated with harmful traitsLess susceptible to inbreeding depression
Genetic DiseasesMore susceptible to recessive genetic diseases if the allele carries harmful mutationsLess susceptible to recessive genetic diseases as the dominant allele often masks harmful mutations
Genetic TestingEasier to determine the genotypeMay require DNA sequencing or specific tests to identify the alleles
Probability of Passing on AllelesAlways passes on the same allele to offspringCan pass on either of the two alleles to offspring with equal probability
SymbolizationHomozygous dominant is represented as AA and homozygous recessive as aaHeterozygous is represented as Aa