Comparison between Fibrous and Globular proteins

Let me share with you a comparison between Fibrous and Globular proteins.


Aspect Fibrous Proteins Globular Proteins
Structure Long and narrow, usually fiber-like or sheet-like Compact, roughly spherical or globular
Amino acid composition Predominantly composed of repetitive amino acid sequences Varied amino acid sequences, often with a mix of hydrophobic and hydrophilic residues
Solubility Insoluble or poorly soluble in water Generally soluble in water
Function Structural roles, often providing strength and support to tissues Diverse functions, including enzymes, antibodies, transport proteins, etc.
Shape Long and extended Compact and rounded
Structure Secondary structure Tertiary structure
Nature Non- Crystalline Crystalline
Flexibility Relatively inflexible Generally more flexible
Water content Low water content High water content



·        Provides tensile strength to tissues (collagen)

·        Forms protective layers (keratin)

·        Catalyzes biochemical reactions (enzymes)

·        Transports oxygen (hemoglobin)

·        Recognizes and binds to foreign substances (antibodies)

Presence Found in connective tissues, hair, skin and nails Found throughout the body, including blood, enzymes in cells, and immune system proteins
Examples ·        Collagen

·        Keratin

·        Elastin

·        Fibrin

·        Hemoglobin

·        Insulin

·        Antibodies

·        Enzymes