Comparison between DNA and Chromosomes

By: Prof. Dr. Fazal Rehman Shamil | Last updated: February 3, 2024

Let me share with you a comparison between DNA and Chromosomes.

Aspect        DNA Chromosomes
IntroductionA long molecule that carries genetic information in the form of a double helixThread-like structures made of DNA and associated proteins found in the cell’s nucleus
OccurrenceFound in the cell nucleus, mitochondria and chloroplastsLocated within the cell nucleus of eukaryotic organisms
CompositionComposed of nucleotides (A, T, C, and G) that form base pairs (A-T and C-G)Composed of DNA molecules coiled around proteins, primarily histones
FunctionCarries genetic information and instructions for protein synthesisCarry and protect genetic information in a condensed and organized form
NumberTypically, organisms have one or two copies of DNA per cell depending on ploidy (diploid or haploid)Typically, organisms have a set number of chromosomes, with variations among species; humans have 46 chromosomes (23 pairs)
StructureDouble-stranded helix structure with a sugar-phosphate backbone and nitrogenous basesConsist of two sister chromatids held together by a centromere
ReplicationDNA replication occurs during the cell cycle to create two identical DNA moleculesChromosomes replicate during the S phase of the cell cycle
PackagingDNA is packaged into compact structures called chromosomesChromosomes condense and coil during cell division
InheritanceDNA carries genetic information from one generation to the next through cell division and reproductionChromosomes are passed from parent to offspring during sexual reproduction
VariationMutations in DNA can result in genetic diversity and evolutionVariations in chromosome number or structure can lead to genetic disorders