| Adjective | Meaning | Example Sentence |
| Agonizing | Causing extreme physical or emotional pain | The agonizing despair was felt by everyone who knew him. |
| Consuming | Overwhelming and all-encompassing | The consuming despair affected every aspect of his life. |
| Crushing | Oppressively heavy and disheartening | The crushing despair was hard to bear. |
| Desolate | Empty and devoid of hope | The desolate feeling of despair was pervasive. |
| Devastated | Extremely upset and emotionally crushed | She was devastated by the news of the loss. |
| Heart-wrenching | Extremely distressing and saddening | The heart-wrenching despair was palpable. |
| Hopeless | Without hope or optimism | He felt completely hopeless in the situation. |
| Overwhelming | Intense and difficult to handle | The overwhelming despair left her speechless. |
| Profound | Deep and intense in feeling | The profound despair was evident in his eyes. |
| Unbearable | Too difficult to endure | The unbearable despair made it hard to function. |
